Ontology highlight
ABSTRACT:
SUBMITTER: Szogi T
PROVIDER: S-EPMC6627374 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Szögi Titanilla T Schuster Ildikó I Borbély Emőke E Gyebrovszki Andrea A Bozsó Zsolt Z Gera János J Rajkó Róbert R Sántha Miklós M Penke Botond B Fülöp Lívia L
International journal of molecular sciences 20190622 12
Regulated intramembrane proteolysis (RIP) of the amyloid precursor protein (APP) leads to the formation of fragments, among which the intracellular domain of APP (AICD) was also identified to be a causative of early pathological events. AICD-counteracting proteins, such as Fe65, may serve as alternative therapeutic targets of Alzheimer's disease (AD). The detection of elevated levels of Fe65 in the brains of both human patients and APP transgenic mice may further strengthen the hypothesis that i ...[more]