No Interaction between Polymorphisms Related to Vitamin A Metabolism and Vitamin A Intake in Relation to Colorectal Cancer in a Prospective Danish Cohort.

ABSTRACT: Although vitamin A is essential for gut immune cell trafficking (paramount for the intestinal immune system), epidemiological studies on the role of vitamin A in colorectal cancer (CRC) aetiology are conflicting. By using functional polymorphisms, gene-environment (GxE) interaction analyses may identify the biological effects (or "mechanism of action") of environmental factors on CRC aetiology. Potential interactions between dietary or supplemental vitamin A intake and genetic variation in the vitamin A metabolic pathway genes related to risk of CRC were studied. We used a nested case-cohort design within the Danish "Diet, Cancer and Health" cohort, with prospectively collected lifestyle information from 57,053 participants, and the Cox proportional hazard models and likelihood ratio test.

SUBMITTER: Andersen V 

PROVIDER: S-EPMC6627526 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature