Is TRPA1 Burning Down TRPV1 as Druggable Target for the Treatment of Chronic Pain?
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ABSTRACT:
SUBMITTER: Giorgi S
PROVIDER: S-EPMC6627658 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
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Is TRPA1 <i>Burning Down</i> TRPV1 as Druggable Target for the Treatment of Chronic Pain?
Giorgi Simona S Nikolaeva-Koleva Magdalena M Alarcón-Alarcón David D Butrón Laura L González-Rodríguez Sara S
International journal of molecular sciences 20190614 12
Over the last decades, a great array of molecular mediators have been identified as potential targets for the treatment of chronic pain. Among these mediators, transient receptor potential (TRP) channel superfamily members have been thoroughly studied. Namely, the nonselective cationic channel, transient receptor potential ankyrin subtype 1 (TRPA1), has been described as a chemical nocisensor involved in noxious cold and mechanical sensation and as rivalling TRPV1, which traditionally has been c ...[more]
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