Ontology highlight
ABSTRACT:
SUBMITTER: Follini E
PROVIDER: S-EPMC6627878 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Follini Elena E Marchesini Matteo M Roti Giovanni G
International journal of molecular sciences 20190620 12
Chemoresistance is a major cause of recurrence and death from T-cell acute lymphoblastic leukemia (T-ALL), both in adult and pediatric patients. In the majority of cases, drug-resistant disease is treated by selecting a combination of other drugs, without understanding the molecular mechanisms by which malignant cells escape chemotherapeutic treatments, even though a more detailed genomic characterization and the identification of actionable disease targets may enable informed decision of new ag ...[more]