Ontology highlight
ABSTRACT:
SUBMITTER: Yao Y
PROVIDER: S-EPMC6628122 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Yao Yuying Y Zhou Zijun Z Li Liuyou L Li Junchen J Huang Lixun L Li Jiangchao J Qi Cuiling C Zheng Lingyun L Wang Lijing L Zhang Qian-Qian QQ
Cells 20190625 6
Slit2 (slit guidance ligand 2), a ligand of the Roundabout1 (Robo1) transmembrane receptor, is often overexpressed in colorectal carcinomas (CRCs). In this study, we performed data mining in the Metabolic gEne RApid Visualizer (MERAV) database and found that Slit2 and TGF-β1 (Transforming growth factor-β1) are highly expressed in carcinomas relative to those in tumor-free tissues from healthy volunteers or wild type mice. Furthermore, expression of Slit2 and TGF-β1 in CRCs increases with patholo ...[more]