Ontology highlight
ABSTRACT:
SUBMITTER: Collina F
PROVIDER: S-EPMC6628138 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Collina Francesca F La Sala Lucia L Liotti Federica F Prevete Nella N La Mantia Elvira E Chiofalo Maria Grazia MG Aquino Gabriella G Arenare Laura L Cantile Monica M Liguori Giuseppina G Di Gennaro Francesca F Pezzullo Luciano L Losito Nunzia Simona NS Vecchio Giancarlo G Botti Gerardo G Melillo Rosa Marina RM Franco Renato R
Cancers 20190607 6
Papillary thyroid carcinomas (PTCs) have an excellent prognosis, but a fraction of them show aggressive behavior, becoming radioiodine (RAI)-resistant and/or metastatic. AXL (Anexelekto) is a tyrosine kinase receptor regulating viability, invasiveness and chemoresistance in various human cancers, including PTCs. Here, we analyze the role of AXL in PTC prognosis and as a marker of RAI refractoriness. Immunohistochemistry was used to assess AXL positivity in a cohort of human PTC samples. Normal a ...[more]