Ontology highlight
ABSTRACT:
SUBMITTER: Bae Y
PROVIDER: S-EPMC6628158 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Bae Yeonju Y Kim Ajung A Cho Chang-Hoon CH Kim Donggyu D Jung Hyun-Gug HG Kim Seong-Seop SS Yoo Jiyun J Park Jae-Yong JY Hwang Eun Mi EM
Cells 20190609 6
Volume-regulated anion channels (VRACs) are involved in cellular functions such as regulation of cell volume, proliferation, migration, and cell death. Although leucine-rich repeat-containing 8A (LRRC8A) has been characterized as a molecular component of VRACs, here we show that Drosophila melanogaster tweety homologue 1 and 2 (TTYH1 and TTYH2) are critical for VRAC currents in cancer cells. LRRC8A-independent VRAC currents were present in the gastric cancer cell line SNU-601, but almost complet ...[more]