Ontology highlight
ABSTRACT:
SUBMITTER: Zhao J
PROVIDER: S-EPMC6628179 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Zhao Jiangang J Schlößer Hans A HA Wang Zhefang Z Qin Jie J Li Jiahui J Popp Felix F Popp Marie Christine MC Alakus Hakan H Chon Seung-Hun SH Hansen Hinrich P HP Neiss Wolfram F WF Jauch Karl-Walter KW Bruns Christiane J CJ Zhao Yue Y
Cancers 20190622 6
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies. Tumor-derived extracellular vesicles (EVs) induce pre-metastatic niche formation to promote metastasis. We isolated EVs from a highly-metastatic pancreatic cancer cell line and patient-derived primary cancer cells by ultracentrifugation. The protein content of EVs was analyzed by mass spectrometry. The effects of PDAC-derived EVs on natural kill (NK) cells were investigated by flow cytometry. The serum EVs' TGF-β1 le ...[more]