Ontology highlight
ABSTRACT:
SUBMITTER: Sparks SM
PROVIDER: S-EPMC6628572 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Sparks Steven M SM Danger Dana P DP Hoekstra William J WJ Leesnitzer Tony T Schotzinger Robert J RJ Yates Christopher M CM Becherer J David JD
ACS medicinal chemistry letters 20190607 7
Excess aldosterone production and signaling are primary contributors to numerous cardiovascular disorders including primary aldosteronism and resistant hypertension. Recently, inhibition of aldosterone synthesis via the enzyme aldosterone synthase (CYP11B2) has been pursued to ameliorate the negative effects of elevated aldosterone. Herein, we report the development of aldosterone synthase inhibitors using a pyrimidine-based metal binding group leading to the highly selective CYP11B2 inhibitor < ...[more]