Sustained virological response does not improve long-term glycaemic control in patients with type 2 diabetes and chronic hepatitis C.

ABSTRACT:

Background

Sustained virological response to treatment for chronic hepatitis C virus may improve short-term glucose control among patients with type 2 diabetes, but the long-term impact remains largely unknown. We used data from the Chronic Hepatitis Cohort Study to investigate the impact of sustained virological response on long-term trends in haemoglobin A1c in patients with type 2 diabetes.

Methods

"Index date" was defined as the date of treatment initiation (treated patients) or hepatitis C virus diagnosis (untreated patients). To address treatment selection bias, we used a propensity score approach. We used a piecewise, linear spline, mixed-effects model to evaluate changes in haemoglobin A1c over a 5-year period.

Results

Our sample included 384 hepatitis C virus

SUBMITTER: Li J 

PROVIDER: S-EPMC6628708 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature