Ontology highlight
ABSTRACT:
SUBMITTER: Lee Y
PROVIDER: S-EPMC6628997 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Lee Yunsung Y Choufani Sanaa S Weksberg Rosanna R Wilson Samantha L SL Yuan Victor V Burt Amber A Marsit Carmen C Lu Ake T AT Ritz Beate B Bohlin Jon J Gjessing Håkon K HK Harris Jennifer R JR Magnus Per P Binder Alexandra M AM Robinson Wendy P WP Jugessur Astanand A Horvath Steve S
Aging 20190601 12
The human pan-tissue epigenetic clock is widely used for estimating age across the entire lifespan, but it does not lend itself well to estimating gestational age (GA) based on placental DNAm methylation (DNAm) data. We replicate previous findings demonstrating a strong correlation between GA and genome-wide DNAm changes. Using substantially more DNAm arrays (n=1,102 in the training set) than a previous study, we present three new placental epigenetic clocks: 1) a robust placental clock (RPC) wh ...[more]