Ontology highlight
ABSTRACT:
SUBMITTER: Kono M
PROVIDER: S-EPMC6629104 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Kono Michihito M Maeda Kayaho K Stocton-Gavanescu Irina I Pan Wenliang W Umeda Masataka M Katsuyama Eri E Burbano Catalina C Orite Seo Yeon K SYK Vukelic Milena M Tsokos Maria G MG Yoshida Nobuya N Tsokos George C GC
JCI insight 20190620 12
Th1 and Th17 are important in the pathogenesis of autoimmune diseases and they depend on glycolysis as a source of energy. T cell antigen receptor signaling phosphorylates a serine/threonine kinase, calcium/calmodulin-dependent protein kinase IV (CaMK4), and promotes glycolysis. Based on these findings we hypothesized that CaMK4 promotes glycolysis. Camk4-deficient CD4+ T cells and cells treated with a CaMK4 inhibitor had less glycolysis compared with their counterparts. Pull-down of CaMK4 and m ...[more]