Unknown

Dataset Information

0

Sex differences in IL-17 contribute to chronicity in male versus female urinary tract infection.


ABSTRACT: Sex-based differences influence incidence and outcome of infectious disease. Women have a significantly greater incidence of urinary tract infection (UTI) than men, yet, conversely, male UTI is more persistent with greater associated morbidity. Mechanisms underlying these sex-based differences are unknown, in part due to a lack of experimental models. We optimized a model to transurethrally infect male mice and directly compared UTI in both sexes. Although both sexes were initially equally colonized by uropathogenic E. coli, only male and testosterone-treated female mice remained chronically infected for up to 4 weeks. Female mice had more robust innate responses, including higher IL-17 expression, and increased ?? T cells and group 3 innate lymphoid cells in the bladder following infection. Accordingly, neutralizing IL-17 abolished resolution in female mice, identifying a cytokine pathway necessary for bacterial clearance. Our findings support the concept that sex-based responses to UTI contribute to impaired innate immunity in males and provide a rationale for non-antibiotic-based immune targeting to improve the response to UTI.

SUBMITTER: Zychlinsky Scharff A 

PROVIDER: S-EPMC6629110 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

Sex differences in IL-17 contribute to chronicity in male versus female urinary tract infection.

Zychlinsky Scharff Anna A   Rousseau Matthieu M   Lacerda Mariano Livia L   Canton Tracy T   Consiglio Camila Rosat CR   Albert Matthew L ML   Fontes Magnus M   Duffy Darragh D   Ingersoll Molly A MA  

JCI insight 20190530


Sex-based differences influence incidence and outcome of infectious disease. Women have a significantly greater incidence of urinary tract infection (UTI) than men, yet, conversely, male UTI is more persistent with greater associated morbidity. Mechanisms underlying these sex-based differences are unknown, in part due to a lack of experimental models. We optimized a model to transurethrally infect male mice and directly compared UTI in both sexes. Although both sexes were initially equally colon  ...[more]

Similar Datasets

2020-08-05 | GSE155676 | GEO
| S-EPMC7230723 | biostudies-literature
| S-EPMC4692505 | biostudies-literature
| S-EPMC8581775 | biostudies-literature
| S-EPMC7676269 | biostudies-literature
| S-EPMC4432053 | biostudies-literature
| S-EPMC5789812 | biostudies-other
| S-EPMC10777155 | biostudies-literature
| S-EPMC7660821 | biostudies-literature
| S-EPMC6279840 | biostudies-other