Ontology highlight
ABSTRACT:
SUBMITTER: Zychlinsky Scharff A
PROVIDER: S-EPMC6629110 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Zychlinsky Scharff Anna A Rousseau Matthieu M Lacerda Mariano Livia L Canton Tracy T Consiglio Camila Rosat CR Albert Matthew L ML Fontes Magnus M Duffy Darragh D Ingersoll Molly A MA
JCI insight 20190530
Sex-based differences influence incidence and outcome of infectious disease. Women have a significantly greater incidence of urinary tract infection (UTI) than men, yet, conversely, male UTI is more persistent with greater associated morbidity. Mechanisms underlying these sex-based differences are unknown, in part due to a lack of experimental models. We optimized a model to transurethrally infect male mice and directly compared UTI in both sexes. Although both sexes were initially equally colon ...[more]