Ontology highlight
ABSTRACT:
SUBMITTER: Vila IK
PROVIDER: S-EPMC6629239 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Vila Isabelle K IK Park Mi Kyung MK Setijono Stephanie Rebecca SR Yao Yixin Y Kim Hyejin H Badin Pierre-Marie PM Choi Sekyu S Narkar Vihang V Choi Sung-Woo SW Chung Jongkyeong J Moro Cedric C Song Su Jung SJ Song Min Sup MS
JCI insight 20190711 13
Ubiquitin-conjugating enzyme E2O (UBE2O) is expressed preferentially in metabolic tissues, but its role in regulating energy homeostasis has yet to be defined. Here we find that UBE2O is markedly upregulated in obese subjects with type 2 diabetes and show that whole-body disruption of Ube2o in mouse models in vivo results in improved metabolic profiles and resistance to high-fat diet-induced (HFD-induced) obesity and metabolic syndrome. With no difference in nutrient intake, Ube2o-/- mice were l ...[more]