Ontology highlight
ABSTRACT:
SUBMITTER: Goff KM
PROVIDER: S-EPMC6629374 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
eLife 20190708
Dravet Syndrome (DS) is a severe neurodevelopmental disorder caused by pathogenic loss of function variants in the gene <i>SCN1A</i> which encodes the voltage gated sodium (Na<sup>+</sup>) channel subunit Nav1.1. GABAergic interneurons expressing parvalbumin (PV-INs) and somatostatin (SST-INs) exhibit impaired excitability in DS (<i>Scn1a</i><sup>+/-</sup>) mice. However, the function of a third major class of interneurons in DS - those expressing vasoactive intestinal peptide (VIP-IN) -is unkno ...[more]