Acid Base Balance and Progression of Kidney Disease.
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ABSTRACT:
SUBMITTER: Chen W
PROVIDER: S-EPMC6629436 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
Acid Base Balance and Progression of Kidney Disease.
Chen Wei W Levy David S DS Abramowitz Matthew K MK
Seminars in nephrology 20190701 4
A large body of work in animals and human beings supports the hypothesis that metabolic acidosis has a deleterious effect on the progression of kidney disease. Alkali therapy, whether pharmacologically or through dietary intervention, appears to slow CKD progression, but an appropriately powered randomized controlled trial with a low risk of bias is required to reach a more definitive conclusion. Recent work on urinary ammonium excretion has shown that the development of prognostic tools related ...[more]
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