Environmental conditions shape the nature of a minimal bacterial genome.
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ABSTRACT:
SUBMITTER: Antczak M
PROVIDER: S-EPMC6629657 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
Environmental conditions shape the nature of a minimal bacterial genome.
Antczak Magdalena M Michaelis Martin M Wass Mark N MN
Nature communications 20190715 1
Of the 473 genes in the genome of the bacterium with the smallest genome generated to date, 149 genes have unknown function, emphasising a universal problem; less than 1% of proteins have experimentally determined annotations. Here, we combine the results from state-of-the-art in silico methods for functional annotation and assign functions to 66 of the 149 proteins. Proteins that are still not annotated lack orthologues, lack protein domains, and/ or are membrane proteins. Twenty-four likely tr ...[more]
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