Ontology highlight
ABSTRACT:
SUBMITTER: Sharma S
PROVIDER: S-EPMC6629679 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Sharma Shruti S Carmona Antonio A Skowronek Agnieszka A Yu Fangyan F Collins Mark O MO Naik Sindhu S Murzeau Claire M CM Tseng Pei-Li PL Erdmann Kai S KS
Nature communications 20190715 1
Fas plays a major role in regulating ligand-induced apoptosis in many cell types. It is well known that several cancers demonstrate reduced cell surface levels of Fas and thus escape a potential control system via ligand-induced apoptosis, although underlying mechanisms are unclear. Here we report that the endosome associated trafficking regulator 1 (ENTR1), controls cell surface levels of Fas and Fas-mediated apoptotic signalling. ENTR1 regulates, via binding to the coiled coil domain protein D ...[more]