An intronic variant in the GCKR gene is associated with multiple lipids.
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ABSTRACT:
SUBMITTER: Fernandes Silva L
PROVIDER: S-EPMC6629684 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
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An intronic variant in the GCKR gene is associated with multiple lipids.
Fernandes Silva Lilian L Vangipurapu Jagadish J Kuulasmaa Teemu T Laakso Markku M
Scientific reports 20190715 1
Previous studies have shown that an intronic variant rs780094 of the GCKR gene (glucokinase regulatory protein) is significantly associated with several metabolites, but the associations of this genetic variant with different lipids is largely unknown. Therefore, we applied metabolomics approach to measure metabolites in a large Finnish population sample (METSIM study) to investigate their associations with rs780094 of GCKR. We measured metabolites by mass spectrometry from 5,181 participants. P ...[more]
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