Comparative study of ?-cyclodextrin, ?-cyclodextrin and 4-tert-butylcalix[8]arene ionophores as electroactive materials for the construction of new sensors for trazodone based on host-guest recognition.

ABSTRACT: Background:Trazodone (TRZ) is a second-generation non-tricyclic antidepressant derived from a triazolopyridine derivative, which is mainly used to treat emotional disorders and conditions related to depressive disorders. Purpose:This study investigated the design, development and characteristics of polyvinyl chloride (PVC) membrane sensors for trazodone HCl (TRZ). Methods:The developed sensing membranes were constructed using ?-cyclodextrin (?-CD; sensor 1), ?-cyclodextrin (?-CD; sensor 2) or 4-tert-butylcalix[8]arene (t-BC8; sensor 3) ionophores as sensing materials in addition to ionic sites and dioctyl phthalate in the PVC matrix. Results:Sensors 1, 2 and 3 displayed fast, stable and near-Nernstian response over a relatively wide trazodone concentration range (7.0×10-6-1×10-3, 5.0×10-5-1×10-3and 8.0×10-6-1.0×10-3 M, respectively), with detection limits of 2.2×10-6, 1.5×10-5 and 2.42×10-6 M, respectively in the pH range of 3.0-6.0. The sensors demonstrated good selectivity for TRZ in the presence of different ionic compounds. The accuracy and precision of the proposed sensors were assessed by the determination of 40.7 ?g/ml of TRZ, which showed average recoveries of 99.6%, 99.1% and 98.5% with mean relative standard deviations of 2.4%, 2.5% and 2.6% for sensor 1, 2 and 3 respectively. Molecular modeling was used to calculate the host-guest binding energy. The lowest free binding energy was -6.243, -5.752 and -5.7105 kcal/mol for 1:1 stoichiometry host-guest complexes of trazodone and ?-CD, ?-CD and t-BC8, respectively, which was in-line with a Nernstian response. Conclusion:The investigated methods can be applied for the determination of TRZ in pharmaceutical preparations. The results of investigated dosage-form of TRZ show good agreement with those using the US Pharmacopeia method.

SUBMITTER: Alrabiah H 

PROVIDER: S-EPMC6630091 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature