Ontology highlight
ABSTRACT:
SUBMITTER: Gruber M
PROVIDER: S-EPMC6630176 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Nature 20190529 7762
How the genomic features of a patient's cancer relate to individual disease kinetics remains poorly understood. Here we used the indolent growth dynamics of chronic lymphocytic leukaemia (CLL) to analyse the growth rates and corresponding genomic patterns of leukaemia cells from 107 patients with CLL, spanning decades-long disease courses. We found that CLL commonly demonstrates not only exponential expansion but also logistic growth, which is sigmoidal and reaches a certain steady-state level. ...[more]