Norovirus Attachment and Entry.
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ABSTRACT:
SUBMITTER: Graziano VR
PROVIDER: S-EPMC6630345 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
Human norovirus is a major human pathogen causing the majority of cases of viral gastroenteritis globally. Viral entry is the first step of the viral life cycle and is a significant determinant of cell tropism, host range, immune interactions, and pathogenesis. Bile salts and histo-blood group antigens are key mediators of norovirus entry; however, the molecular mechanisms by which these molecules promote infection and the identity of a potential human norovirus receptor remain unknown. Recently ...[more]
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