Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors.

ABSTRACT: Neutrophils are a component of the tumor microenvironment and have been predominantly associated with cancer progression. Using a genetic approach complemented by adoptive transfer, we found that neutrophils are essential for resistance against primary 3-methylcholantrene-induced carcinogenesis. Neutrophils were essential for the activation of an interferon-?-dependent pathway of immune resistance, associated with polarization of a subset of CD4- CD8- unconventional ?? T cells (UTC??). Bulk and single-cell RNA sequencing (scRNA-seq) analyses unveiled the innate-like features and diversity of UTC?? associated with neutrophil-dependent anti-sarcoma immunity. In selected human tumors, including undifferentiated pleomorphic sarcoma, CSF3R expression, a neutrophil signature and neutrophil infiltration were associated with a type 1 immune response and better clinical outcome. Thus, neutrophils driving UTC?? polarization and type 1 immunity are essential for resistance against murine sarcomas and selected human tumors.

SUBMITTER: Ponzetta A 

PROVIDER: S-EPMC6630709 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature