Functionalized Gold Nanoparticles as Contrast Agents for Proton and Dual Proton/Fluorine MRI.

ABSTRACT: Gold nanoparticles carrying fluorinated ligands in their monolayer are, by themselves, contrast agents for 19F magnetic resonance imaging displaying high sensitivity because of the high density of fluorine nuclei achievable by grafting suitable ligands on the gold core surface. Functionalization of these nanoparticles with Gd(III) chelates allows adding a further functional activity to these systems, developing materials also acting as contrast agents for proton magnetic resonance imaging. These dual mode contrast agents may allow capitalizing on the benefits of 1H and 19F magnetic resonance imaging in a single diagnostic session. In this work, we describe a proof of principle of this approach by studying these nanoparticles in a high field preclinical scanner. The Gd(III) centers within t

SUBMITTER: Sologan M 

PROVIDER: S-EPMC6631171 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature