Ontology highlight
ABSTRACT:
SUBMITTER: Shah BS
PROVIDER: S-EPMC6633394 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Shah Bhavin S BS Shimell Jordan J JJ Bamji Shernaz X SX
Journal of cell science 20190705 13
Protein palmitoylation is the most common post-translational lipid modification in the brain and is mediated by a family of 24 zDHHC enzymes. There has been growing interest in zDHHCs due to mounting evidence that these enzymes play key roles in the development and function of neuronal connections, and the fact that a number of zDHHCs have been associated with neurodevelopmental and neurodegenerative diseases. Loss-of-function variants in several zDHHCs, including zDHHC15, have been identified i ...[more]