Ontology highlight
ABSTRACT:
SUBMITTER: Steevens AR
PROVIDER: S-EPMC6633603 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Steevens Aleta R AR Glatzer Jenna C JC Kellogg Courtney C CC Low Walter C WC Santi Peter A PA Kiernan Amy E AE
Development (Cambridge, England) 20190621 13
The transcription factor sex determining region Y-box 2 (SOX2) is required for the formation of hair cells and supporting cells in the inner ear and is a widely used sensory marker. Paradoxically, we demonstrate via fate mapping that, initially, SOX2 primarily marks nonsensory progenitors in the mouse cochlea, and is not specific to all sensory regions until late otic vesicle stages. SOX2 fate mapping reveals an apical-to-basal gradient of SOX2 expression in the sensory region of the cochlea, re ...[more]