Ontology highlight
ABSTRACT:
SUBMITTER: Lybrand DB
PROVIDER: S-EPMC6633605 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Lybrand Daniel B DB Naiman Misha M Laumann Jessie May JM Boardman Mitzi M Petshow Samuel S Hansen Kevin K Scott Gregory G Wehrli Marcel M
Development (Cambridge, England) 20190702 13
The central regulator of the Wnt/β-catenin pathway is the Axin/APC/GSK3β destruction complex (DC), which, under unstimulated conditions, targets cytoplasmic β-catenin for degradation. How Wnt activation inhibits the DC to permit β-catenin-dependent signaling remains controversial, in part because the DC and its regulation have never been observed <i>in vivo</i> Using bimolecular fluorescence complementation (BiFC) methods, we have now analyzed the activity of the DC under near-physiological cond ...[more]