Ontology highlight
ABSTRACT:
SUBMITTER: Bradley RA
PROVIDER: S-EPMC6633609 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Bradley Robert A RA Shireman Jack J McFalls Caya C Choi Jeea J Canfield Scott G SG Dong Yi Y Liu Katie K Lisota Brianne B Jones Jeffery R JR Petersen Andrew A Bhattacharyya Anita A Palecek Sean P SP Shusta Eric V EV Kendziorski Christina C Zhang Su-Chun SC
Development (Cambridge, England) 20190708 13
Astrocytes display diverse morphologies in different regions of the central nervous system. Whether astrocyte diversity is attributable to developmental processes and bears functional consequences, especially in humans, is unknown. RNA-seq of human pluripotent stem cell-derived regional astrocytes revealed distinct transcript profiles, suggesting differential functional properties. This was confirmed by differential calcium signaling as well as effects on neurite growth and blood-brain barrier f ...[more]