Ontology highlight
ABSTRACT:
SUBMITTER: Ohnishi H
PROVIDER: S-EPMC6634652 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Ohnishi Hiroshi H Murata Takaaki T Kusakari Shinya S Hayashi Yuriko Y Takao Keizo K Maruyama Toshi T Ago Yukio Y Koda Ken K Jin Feng-Jie FJ Okawa Katsuya K Oldenborg Per-Arne PA Okazawa Hideki H Murata Yoji Y Furuya Nobuhiko N Matsuda Toshio T Miyakawa Tsuyoshi T Matozaki Takashi T
The Journal of neuroscience : the official journal of the Society for Neuroscience 20100801 31
Severe stress induces changes in neuronal function that are implicated in stress-related disorders such as depression. The molecular mechanisms underlying the response of the brain to stress remain primarily unknown, however. Signal regulatory protein alpha (SIRPalpha) is an Ig-superfamily protein that undergoes tyrosine phosphorylation and binds the protein tyrosine phosphatase Shp2. Here we show that mice expressing a form of SIRPalpha that lacks most of the cytoplasmic region manifest prolong ...[more]