Ontology highlight
ABSTRACT:
SUBMITTER: Soriano S
PROVIDER: S-EPMC6635372 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Soriano Sergi S Gil-Rivera Minerva M Marroqui Laura L Alonso-Magdalena Paloma P Fuentes Esther E Gustafsson Jan-Ake JA Nadal Angel A Martinez-Pinna Juan J
Scientific reports 20190716 1
17β-Estradiol mediates the sensitivity to pain and is involved in sex differences in nociception. The widespread environmental disrupting chemical bisphenol A (BPA) has estrogenic activity, but its implications in pain are mostly unknown. Here we show that treatment of male mice with BPA (50 µg/kg/day) during 8 days, decreases the latency to pain behavior in response to heat, suggesting increased pain sensitivity. We demonstrate that incubation of dissociated dorsal root ganglia (DRG) nociceptor ...[more]