Cerebellar disruption impairs working memory during evidence accumulation.
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ABSTRACT:
SUBMITTER: Deverett B
PROVIDER: S-EPMC6635393 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
Cerebellar disruption impairs working memory during evidence accumulation.
Deverett Ben B Kislin Mikhail M Tank David W DW Wang Samuel S-H SS
Nature communications 20190716 1
To select actions based on sensory evidence, animals must create and manipulate representations of stimulus information in memory. Here we report that during accumulation of somatosensory evidence, optogenetic manipulation of cerebellar Purkinje cells reduces the accuracy of subsequent memory-guided decisions and causes mice to downweight prior information. Behavioral deficits are consistent with the addition of noise and leak to the evidence accumulation process. We conclude that the cerebellum ...[more]
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