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Fine-Grained Parcellation of the Macaque Nucleus Accumbens by High-Resolution Diffusion Tensor Tractography.


ABSTRACT: Limited in part by the spatial resolution of typical in vivo magnetic resonance imaging (MRI) data, recent neuroimaging studies have only identified a connectivity-based shell-core-like partitioning of the nucleus accumbens (Acb) in humans. This has hindered the process of making a more refined description of the Acb using non-invasive neuroimaging technologies and approaches. In this study, high-resolution ex vivo macaque brain diffusion MRI data were acquired to investigate the tractography-based parcellation of the Acb. Our results identified a shell-core-like partitioning in macaques that is similar to that in humans as well as an alternative solution that subdivided the Acb into four parcels, the medial shell, the lateral shell, the ventral core, and the dorsal core. Furthermore, we characterized the specific anatomical and functional connectivity profiles of these Acb subregions and generalized their specialized functions to establish a fine-grained macaque Acb brainnetome atlas. This atlas should be helpful in neuroimaging, stereotactic surgery, and comparative neuroimaging studies to reveal the neurophysiological substrates of various diseases and cognitive functions associated with the Acb.

SUBMITTER: Xia X 

PROVIDER: S-EPMC6635473 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Fine-Grained Parcellation of the Macaque Nucleus Accumbens by High-Resolution Diffusion Tensor Tractography.

Xia Xiaoluan X   Fan Lingzhong L   Hou Bing B   Zhang Baogui B   Zhang Dan D   Cheng Chen C   Deng Hongxia H   Dong Yunyun Y   Zhao Xudong X   Li Haifang H   Jiang Tianzi T  

Frontiers in neuroscience 20190710


Limited in part by the spatial resolution of typical <i>in vivo</i> magnetic resonance imaging (MRI) data, recent neuroimaging studies have only identified a connectivity-based shell-core-like partitioning of the nucleus accumbens (Acb) in humans. This has hindered the process of making a more refined description of the Acb using non-invasive neuroimaging technologies and approaches. In this study, high-resolution <i>ex vivo</i> macaque brain diffusion MRI data were acquired to investigate the t  ...[more]

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