Ontology highlight
ABSTRACT:
SUBMITTER: Martirosyan A
PROVIDER: S-EPMC6635959 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Martirosyan Anush A Aminov Rustam R Manukyan Gayane G
Frontiers in immunology 20190710
Antiphospholipid antibodies (aPLs) comprise a diverse family of autoantibodies targeted against proteins with the affinity toward negatively charged phospholipids or protein-phospholipid complexes. Their clinical significance, including prothrombotic potential of anti-cardiolipin antibodies (aCLs), anti-β2-glycoprotein I antibodies (aβ2-GPIs), and lupus anti-coagulant (LA), is well-established. However, the ontogeny of these pathogenic aPLs remains less clear. While transient appearance of aPLs ...[more]