Effects of weight change on apolipoprotein B-containing emerging atherosclerotic cardiovascular disease (ASCVD) risk factors.

ABSTRACT: BACKGROUND AND AIMS:Non-high-density (HDL)-cholesterol, low-density lipoprotein (LDL)-particle number, apolipoprotein B, lipoprotein(a) (Lp(a)), and small-dense (sdLDL) and large-buoyant (lbLDL) LDL-subfractions are emerging apo B-containing atherosclerotic cardiovascular disease (ASCVD) risk factors. Current guidelines emphasize lifestyle, including weight loss, for ASCVD risk management. Whether weight change affects these emerging risk factors beyond that predicted by traditional triglyceride and LDL-cholesterol measurements remains to be determined. METHOD:Regression analyses of fasting ?apo B-containing lipoproteins vs. ?BMI were examined in a large anonymized clinical laboratory database of 33,165 subjects who did not report use of lipid-lowering medications. Regression slopes (±SE) were estimated as: *?mmol/L per ?kg/m2, †?g/L per ?kg/m2, ‡?% per ?kg/m2, and §??mol/L per ?kg/m2. RESULTS:When adjusted for age, ?BMI was significantly related to ?nonHDL-cholesterol (males: 0.0238?±?0.0041, P?=?7.9?×?10-?9; females: 0.0330?±?0.0037, P?

SUBMITTER: Dansinger ML 

PROVIDER: S-EPMC6636168 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature