Ontology highlight
ABSTRACT:
SUBMITTER: Manning JR
PROVIDER: S-EPMC6636327 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Manning Janet R JR Thapa Dharendra D Zhang Manling M Stoner Michael W MW Traba Javier J Corey Catherine C Shiva Sruti S Sack Michael N MN Scott Iain I
The Biochemical journal 20190619 12
GCN5L1 regulates protein acetylation and mitochondrial energy metabolism in diverse cell types. In the heart, loss of GCN5L1 sensitizes the myocardium to injury from exposure to nutritional excess and ischemia/reperfusion injury. This phenotype is associated with the reduced acetylation of metabolic enzymes and elevated mitochondrial reactive oxygen species (ROS) generation, although the direct molecular targets of GCN5L1 remain largely unknown. In this study, we sought to determine the mechanis ...[more]