Ontology highlight
ABSTRACT:
SUBMITTER: Kim HM
PROVIDER: S-EPMC6636332 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Kim Hyun Min HM Han Jeong Woo JW Chan Jefferson Y JY
Gene 20160303 1
Nrf1 (also referred to as NFE2L1) is a member of the CNC-bZIP family of transcription factors that are characterized by a highly conserved CNC-domain, and a basic-leucine zipper domain required for dimerization and DNA binding. Nrf1 is ubiquitously expressed across tissue and cell types as various isoforms, and is induced by stress signals from a broad spectrum of stimuli. Evidence indicates that Nrf1 plays an important role in regulating a range of cellular functions including oxidative stress ...[more]