Classification and Nomenclature of CRISPR-Cas Systems: Where from Here?
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ABSTRACT:
SUBMITTER: Makarova KS
PROVIDER: S-EPMC6636873 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Publications
Classification and Nomenclature of CRISPR-Cas Systems: Where from Here?
Makarova Kira S KS Wolf Yuri I YI Koonin Eugene V EV
The CRISPR journal 20181001 5
As befits an immune mechanism, CRISPR-Cas systems are highly variable with respect to Cas protein sequences, gene composition, and organization of the genomic loci. Optimal classification of CRISPR-Cas systems and rational nomenclature for CRISPR-associated genes are essential for further progress of CRISPR research. These are highly challenging tasks because of the complexity of CRISPR-Cas and their fast evolution, including frequent module shuffling, as well as the lack of universal markers fo ...[more]
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