Ontology highlight
ABSTRACT:
SUBMITTER: Amrit FRG
PROVIDER: S-EPMC6637209 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Amrit Francis R G FRG Naim Nikki N Ratnappan Ramesh R Loose Julia J Mason Carter C Steenberge Laura L McClendon Brooke T BT Wang Guoqiang G Driscoll Monica M Yanowitz Judith L JL Ghazi Arjumand A
Nature communications 20190717 1
Stress resistance and longevity are positively correlated but emerging evidence indicates that they are physiologically distinct. Identifying factors with distinctive roles in these processes is challenging because pro-longevity genes often enhance stress resistance. We demonstrate that TCER-1, the Caenorhabditis elegans homolog of human transcription elongation and splicing factor, TCERG1, has opposite effects on lifespan and stress resistance. We previously showed that tcer-1 promotes longevit ...[more]