Ontology highlight
ABSTRACT:
SUBMITTER: Corbett BF
PROVIDER: S-EPMC6637233 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Corbett Brian F BF Luz Sandra S Arner Jay J Pearson-Leary Jiah J Sengupta Abhishek A Taylor Deanne D Gehrman Philip P Ross Richard R Bhatnagar Seema S
Nature communications 20190717 1
Stress can promote the development of psychiatric disorders, though some individuals are more vulnerable to stress compared to others who are more resilient. Here we show that the sphingosine-1-phosphate receptor 3 (S1PR3) in the medial prefrontal cortex (mPFC) of rats regulates resilience to chronic social defeat stress. S1PR3 expression is elevated in the mPFC of resilient compared to vulnerable and control rats. Virally-mediated over-expression of S1PR3 in the mPFC produces a resilient phenot ...[more]