Multilayered control of exon acquisition permits the emergence of novel forms of regulatory control.

ABSTRACT:

Background

The long introns of mammals are pools of evolutionary potential due to the multiplicity of sequences that permit the acquisition of novel exons. However, the permissibility of genes to this type of acquisition and its influence on the evolution of cell regulation is poorly understood.

Results

Here, we observe that human genes are highly permissive to the inclusion of novel exonic regions permitting the emergence of novel regulatory features. Our analysis reveals the potential for novel exon acquisition to occur in over 30% of evaluated human genes. Regulatory processes including the rate of splicing efficiency and RNA polymerase II (RNAPII) elongation control this process by modulating the "window of opportunity" for spliceosomal recognition. DNA damage alters thi

SUBMITTER: Avgan N 

PROVIDER: S-EPMC6637531 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature