Ontology highlight
ABSTRACT:
SUBMITTER: Hino K
PROVIDER: S-EPMC6639038 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Hino Keiko K Simó Sergi S Cooper Jonathan A JA
Developmental dynamics : an official publication of the American Association of Anatomists 20181107 11
<h4>Background</h4>The E3 Cullin 5-RING ubiquitin ligase (CRL5) is a multiprotein complex that has recently been highlighted as a major regulator of central nervous system development. Cullin 5 (Cul5) and the RING finger protein Rbx2 are two CRL5 core components required for CRL5 function in the brain, but their full expression patterns and developmental functions have not been described in detail.<h4>Results</h4>Using a gene-trap mouse model for Cul5 and a knock-in-knockout mouse model for Rbx2 ...[more]