Ontology highlight
ABSTRACT:
SUBMITTER: Castets P
PROVIDER: S-EPMC6639401 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Castets Perrine P Rion Nathalie N Théodore Marine M Falcetta Denis D Lin Shuo S Reischl Markus M Wild Franziska F Guérard Laurent L Eickhorst Christopher C Brockhoff Marielle M Guridi Maitea M Ibebunjo Chikwendu C Cruz Joseph J Sinnreich Michael M Rudolf Rüdiger R Glass David J DJ Rüegg Markus A MA
Nature communications 20190718 1
Loss of innervation of skeletal muscle is a determinant event in several muscle diseases. Although several effectors have been identified, the pathways controlling the integrated muscle response to denervation remain largely unknown. Here, we demonstrate that PKB/Akt and mTORC1 play important roles in regulating muscle homeostasis and maintaining neuromuscular endplates after nerve injury. To allow dynamic changes in autophagy, mTORC1 activation must be tightly balanced following denervation. Ac ...[more]