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Fecal short-chain fatty acid concentrations and dysbiosis in dogs with chronic enteropathy.


ABSTRACT:

Background

Accumulating evidence shows an important relationship between the gastrointestinal (GI) microbiota and host health. Microbial metabolites are believed to play a critical role in host-microbial interactions. Short-chain fatty acids (SCFAs) are major end products of bacterial carbohydrate fermentation in the intestinal tract. Decreased concentrations of SCFAs have been observed in humans with GI disease. However, large-scale clinical data in dogs are lacking.

Hypothesis/objective

To evaluate fecal concentrations of SCFAs and the fecal microbiota in healthy control (HC) dogs and dogs with chronic enteropathy (CE).

Animals

Forty-nine privately owned HC dogs and 73 dogs with CE.

Methods

Prospective cohort study. Fecal concentrations of SCFAs were measured using gas chromatography/mass spectrometry. Illumina sequencing and quantitative real-time polymerase chain reaction were utilized to evaluate the fecal microbiota.

Results

Fecal concentrations (median [range] ?mol/g of dry matter) of acetate were lower (P = .03) in dogs with CE (185.8 [20.1-1042.1]) than in HC dogs (224.0 [87.7-672.8]). Propionate were also lower (P?Conclusions and clinical importanceDogs with CE had an altered fecal SCFA concentration accompanied by significant changes of the fecal microbiota.

SUBMITTER: Minamoto Y 

PROVIDER: S-EPMC6639498 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Publications

Fecal short-chain fatty acid concentrations and dysbiosis in dogs with chronic enteropathy.

Minamoto Yasushi Y   Minamoto Tomomi T   Isaiah Anitha A   Sattasathuchana Panpicha P   Buono Agostino A   Rangachari Venkat R VR   McNeely Isaac H IH   Lidbury Jonathan J   Steiner Jörg M JM   Suchodolski Jan S JS  

Journal of veterinary internal medicine 20190517 4


<h4>Background</h4>Accumulating evidence shows an important relationship between the gastrointestinal (GI) microbiota and host health. Microbial metabolites are believed to play a critical role in host-microbial interactions. Short-chain fatty acids (SCFAs) are major end products of bacterial carbohydrate fermentation in the intestinal tract. Decreased concentrations of SCFAs have been observed in humans with GI disease. However, large-scale clinical data in dogs are lacking.<h4>Hypothesis/objec  ...[more]

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