Ontology highlight
ABSTRACT:
SUBMITTER: Belkin S
PROVIDER: S-EPMC6640133 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Journal of computer-aided molecular design 20180712 7
Modulating protein interaction pathways may lead to the cure of many diseases. Known protein-protein inhibitors bind to large pockets on the protein-protein interface. Such large pockets are detected also in the protein-protein complexes without known inhibitors, making such complexes potentially druggable. The inhibitor-binding site is primary defined by the side chains that form the largest pocket in the protein-bound conformation. Low-resolution ligand docking shows that the success rate for ...[more]