Ontology highlight
ABSTRACT:
SUBMITTER: Mir FM
PROVIDER: S-EPMC6640192 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Mir Fatemeh M FM Crisma Marco M Toniolo Claudio C Lubell William D WD
Chemical science 20190610 28
The unique abilities of homo-oligo-adamantyl peptides to adopt α- and γ-turn conformations are demonstrated by X-ray diffraction, and NMR and FT-IR absorption spectroscopies. Assembled by an Ugi multiple component reaction strategy, <i>N</i> <sup>α</sup>-formyl-adamantyl tripeptide iso-propyl and <i>tert</i>-butyl amides are respectively found to adopt an isolated α-turn and an incipient γ-helix conformation by X-ray diffraction crystallography. The shortest example of a single α-turn with ideal ...[more]