Ontology highlight
ABSTRACT:
SUBMITTER: Feldman JL
PROVIDER: S-EPMC6640630 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Feldman Jessica L JL Peterson Craig L CL
Cell reports 20190601 10
The mammalian sirtuin, SIRT6, is a key tumor suppressor that maintains genome stability and regulates transcription, though how SIRT6 family members control genome stability is unclear. Here, we use multiple genome-wide approaches to demonstrate that the yeast SIRT6 homologs, Hst3 and Hst4, prevent genome instability by tuning levels of both coding and noncoding transcription. While nascent RNAs are elevated in the absence of Hst3 and Hst4, a global impact on steady-state mRNAs is masked by the ...[more]