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Unique Ivy-Like Morphology Composed of Poly(lactic acid) and Bacterial Cellulose Cryogel.

ABSTRACT: This study examines the unique morphology and properties of enhanced poly(l-lactic acid) (PLLA) monoliths having a bacterial cellulose (BC) framework. Open-porous BC/PLLA monoliths were successfully prepared using thermally induced phase separation (TIPS) and a freeze-drying technique. The BC/PLLA monoliths exhibited a unique ivy-like structure composed of leaf-like PLLA units and a BC fiber network. We demonstrated for the first time that the interpenetrating BC fiber gives PLLA monoliths four times higher compressive strength than the pristine PLLA. Scanning electron microscopy observation and the N₂ adsorption test revealed that the size of PLLA units and the surface area of the monoliths can be manipulated by varying the starting PLLA concentration during the TIPS process. Moreover, the hydrophilicity of the PLLA monoliths was easily controlled by incorporating BC; the neat PLLA monoliths showed a high static water contact angle of as high as 128.8 ± 1.1°, whereas the BC/PLLA monoliths exhibited a much lower contact angle (102.1 ± 1.7°) and greater absorbability to water.

SUBMITTER: Kanno T

PROVIDER: S-EPMC6641254 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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Unique Ivy-Like Morphology Composed of Poly(lactic acid) and Bacterial Cellulose Cryogel.

Kanno Tomonari T Uyama Hiroshi H

ACS omega 20180119 1

This study examines the unique morphology and properties of enhanced poly(l-lactic acid) (PLLA) monoliths having a bacterial cellulose (BC) framework. Open-porous BC/PLLA monoliths were successfully prepared using thermally induced phase separation (TIPS) and a freeze-drying technique. The BC/PLLA monoliths exhibited a unique ivy-like structure composed of leaf-like PLLA units and a BC fiber network. We demonstrated for the first time that the interpenetrating BC fiber gives PLLA monoliths four ...[more]

PMID: 31457919

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Project description:In the pursuit of continuous improvement in the area of biomaterial design, blends of mixed-substituent polyphosphazenes and poly (lactic acid-glycolic acid) (PLGA) were prepared, and their morphology of phase distributions for the first time was studied. The degradation mechanism and osteocompatibility of the blends were also evaluated for their use as regenerative materials. Poly [(ethyl phenylalanato)25(glycine ethyl glycinato)75phosphazene](PNEPAGEG) and poly [(glycine ethyl glycinato)75(phenylphenoxy)25phosphazene](PNGEGPhPh) were blended with PLGA at various weight ratios to yield different blends, namely PNEPAGEG-PLGA 25:75, PNEPAGEG-PLGA 50:50, PNGEGPhPh-PLGA 25:75, and PNGEGPhPh-PLGA 50:50. The molecular interactions, domain sizes, and phase distributions of the blends were confirmed by atomic force microscopy (AFM) as the PNEPAGEG-PLGA and PNGEGPhPh-PLGA blends showed different domain sizes and phase distributions. Due to the extensive hydrogen bonding within the two polymer components, PNEPAGEG-PLGA exhibited small-sized domains and well-distributed morphology. While for the PNGEGPhPh-PLGA blends, the presence of phenylphenol (PhPh) caused the formation of PLGA large-sized domains as the PLGA formed a continuous phase and PNGEGPhPh constituted a dispersed phase. In addition to AFM results, scanning electron microscopy-energy dispersive X-ray spectrometry (SEM-EDS), differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), and Fourier transform infrared spectroscopy (FTIR) results demonstrated the miscibility of the blends. The PNEPAGEG-PLGA and PNGEGPhPh-PLGA blends presented in situ 3D interconnected porous structures upon degradation in phosphate-buffered saline (PBS) media at 37°C. However, the blends showed different mechanistic pathways to the formations of the pores. The difference in the erosion patterns could be attributed to the nature of molecular attractions that exist in the blends. Furthermore, the novel blends were able to support cell growth as compared to PLGA, and accommodate cell infiltrations, which ultimately augmented surface area for better cell-material interactions.

Dataset Information

Unique Ivy-Like Morphology Composed of Poly(lactic acid) and Bacterial Cellulose Cryogel.

Publications

Unique Ivy-Like Morphology Composed of Poly(lactic acid) and Bacterial Cellulose Cryogel.

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