Highly Structured Polyvinyl Alcohol Porous Carriers: Tuning Inherent Stability and Release Kinetics in Water.

ABSTRACT: Polyvinyl alcohol (PVA) porous carriers were prepared by means of ice templating of aqueous solutions containing of 90 kD and/or 16 kD PVA. The carriers were loaded with traces of a colored probe (methyl orange) to screen their release properties, once immersed in water. The carriers prepared from solutions containing 90 kD and 16 kD PVA resulted in intimate polymer mixtures, exhibiting physical properties that stand in between those of the bare 90 kD or 16 kD PVA end members. The freezing protocols employed were adapted to prepare carriers textured in the form of either monolithic scaffolds (directional constant freezing rate) or millimetric pellets (flash-freeze). Monolithic carriers remain stable in aqueous solution, and the probe release is governed by a swelling-diffusion mechanism. T

SUBMITTER: Sonego JM 

PROVIDER: S-EPMC6641308 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature