The Risk of Treatment-Emergent Mania With Methylphenidate in Bipolar Disorder.

ABSTRACT:

Objective

The authors sought to determine the risk of treatment-emergent mania associated with methylphenidate, used in monotherapy or with a concomitant mood-stabilizing medication, in patients with bipolar disorder.

Method

Using linked Swedish national registries, the authors identified 2,307 adults with bipolar disorder who initiated therapy with methylphenidate between 2006 and 2014. The cohort was divided into two groups: those with and those without concomitant mood-stabilizing treatment. To adjust for individual-specific confounders, including disorder severity, genetic makeup, and early environmental factors, Cox regression analyses were used, conditioning on individual to compare the rate of mania (defined as hospitalization for mania or a new dispensation of stabil

SUBMITTER: Viktorin A 

PROVIDER: S-EPMC6641557 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature