Ontology highlight
ABSTRACT:
SUBMITTER: Laha JK
PROVIDER: S-EPMC6641690 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
ACS omega 20170721 7
A palladium-catalyzed ortho-acylation of tertiary benzamides using arylglyoxylic acids has been described. Unlike the palladium insertion reported to occur in the distorted N-C(O) amide bond of tertiary benzamides, the current study unveils ortho C-H palladation in acylic or cyclic <i>N</i>,<i>N</i>-dialkylbenzamides affording ortho-acylated tertiary benzamides in good to excellent yields. Our experimental study on the mechanism provides information on the tendency of the amide nitrogen toward w ...[more]